A selective NNMT inhibitor studied in adipose tissue metabolism and metabolic research applications. Supplied as lyophilized powder for laboratory use.
Specifications
| Compound | 5-Amino-1MQ |
|---|---|
| Category | Small Molecule |
| SKU | 5-amino-1mq-5mg |
| Price | $80.00 |
| Availability | In stock |
| Intended use | Laboratory research use only |
Compound identity
Reference facts for the compound itself, from PubChem (NIH). They describe the molecule, not a specific batch — batch purity is reported on the certificate of analysis.
| CAS Registry Number | 685079-15-6 |
|---|---|
| IUPAC name | 1-methylquinolin-1-ium-5-amine |
| PubChem CID | 950107 |
5-Amino-1MQ is also written 5-Amino-1MQ peptide, 5Amino1MQ, 5Amino1MQ peptide, 5 Amino 1MQ and 5 Amino 1MQ peptide.
Research questions about this compound
What is the primary function of 5-Amino-1MQ?
5-Amino-1MQ is a selective, cell-permeable small-molecule inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT) . Its primary function in research is to block the catalytic activity of this enzyme, which prevents the consumption of S-adenosylmethionine (SAM) and the methylation of nicotinamide .
Has 5-Amino-1MQ been tested in humans?
No. All current research regarding the metabolic effects of 5-Amino-1MQ, including weight loss and insulin sensitivity improvements, has been conducted in animal models, specifically mice , .
Does 5-Amino-1MQ increase energy expenditure?
In animal models, the inhibition of NNMT by 5-Amino-1MQ has been associated with increased energy expenditure and reduced adipose tissue mass . This is believed to occur through the modulation of cellular metabolic pathways, though this has only been demonstrated in preclinical settings .
Is 5-Amino-1MQ effective for metabolic dysfunction?
Preclinical studies in mice have shown that 5-Amino-1MQ can mitigate obesity-related metabolic dysfunction, such as impaired glucose tolerance . These findings are limited to animal models and do not represent a clinical treatment for human metabolic conditions .
labels, lab notebooks, reorders
5-Amino-1MQ — Reconstitution Calculator
For laboratory research use only. This tool computes the concentration of a reconstituted research solution and the volume that contains a target mass. Vial mass is a product specification, not a dose. It is not medical guidance and does not describe administration to humans or animals.
For laboratory research use only · not for human or animal use. Doses-per-bottle is pure arithmetic (vial mass ÷ target amount), not a dosing recommendation.
